Click here for a complete list of CME opportunities.
The American Academy of HIV Medicine www.aahivm.org
Antiretroviral Resistance
References
- Anastassopoulou CG, Ketas TJ, Klasse PJ, Moore JP. Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41. Proc Natl Acad Sci U S A. 2009;106:5318-5323.
- Baxter JD, Dunn D, White E, et al. Global HIV-1 transmitted drug resistance in the INSIGHT Strategic Timing of AntiRetroviral Treatment Trial. HIV Med. 2015 Apr;16(1):77-87.
- Baxter JD, Mayers DL, Wentworth DN, et al. A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. AIDS. 2000;14:F83-F93..
- Bennett DE, Camacho RJ, Otelea D, et al. Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update. PLoS One. 2009; 4:e4724.
- Cane P, Chrystie I, Dunn D, et al. Time trends in primary resistance to HIV drugs in the United Kingdom: Multicentre observational study. BMJ. 2005;331:1368.
- Castagna A, Maggiolo F, Penco G, et al. Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 Study. J Infect Dis. 2014;210:354-362.
- Cohen CJ, Hunt S, Sension M, et al. A randomized trial assessing the impact of phenotypic resistance testing on antiretroviral therapy. AIDS. 2002;16:579-588.
- Cohen CJ, Molina JM, Cahn P. Efficacy and safety of rilpivirine (TMC278) versus efavirenz at 48 weeks in treatment-naïve, HIV-1-infected patients: Pooled results from the phase III double-blind, randomized ECHO and THRIVE trials. J Acquir Immune Defic Syndr. 2012;60:33-42.
- Das K, Arnold E. HIV-1 reverse transcriptase and antiviral drug resistance. Part 2. Curr Opin Virol. 2013;3:119-128.
- Durant J, Clevenbergh P, Halfon P, et al. Drug-resistance genotyping in HIV-1 therapy: The VIRADAPT randomised controlled trial. Lancet. 1999;353:2195-2199.
- Goetz M, Leduc R, Kostman J, et al. HIV replicative capacity is an independent predictor of disease progression in persons with untreated chronic HIV infection. J Acquir Immune Defic Syndr. 2010;53:472-479.
- Hatano H, Lampiris H, Fransen S, et al. Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy. J Acquir Immune Defic Syndr. 2010;54:389-393.
- Kassaye SG, Grossman Z, Balamane M, et al. Transmitted HIV drug resistance is high and longstanding in metropolitan Washington, DC. Clin Infect Dis. 2016;63(6):836-843.
- McGee KS, Okeke NL, Hunt CB, et al. Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naïve Patient. Open Forum Infect Dis 2018 Nov 8; 5:ofy294. (https://doi.org/10.1093/ofid/ofy294)
- McGovern RA, Thielen A, Mo T, et al. Population-based V3 genotypic tropism assay: A retrospective analysis using screening, samples from the A4001029 and MOTIVATE studies. AIDS. 2010;24:2517-2525.
- Miller V. International perspectives on antiretroviral resistance. Resistance to protease inhibitors. J Acquir Immune Defic Syndr. 2001;26 Suppl 1:S34-S50.
- Molina JM, Cahn P, Grinsztejn, et al. Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naïve adults infected with HIV-1 (ECHO): A phase III randomised double-blind active-controlled trial. Lancet 2011;378:238-246.
- Novak RM, Chen L, MacArthur RD, et al. Prevalence of antiretroviral drug resistance mutations in chronically HIV-infected, treatment-naïve patients: Implications for routine resistance screening before initiation of antiretroviral therapy. Clin Infect Dis. 2005;40:468-474.
- Panichsillapakit T, Smith D, Wertheim T, et al. Prevalence of transmitted HIV drug resistance among recently infected persons in San Diego, California 1996-2013. J Acquir Immune Defic Syndr. 2016;71:228-236.
- Raymond S, Delobel P, Mavigner M, et al. Correlation between genotypic predictions based on V3 sequences and phenotypic determination of HIV-1 tropism. AIDS. 2008;22:F11-F16.
- Saag MS, Benson CA, Gandhi MD, et al. Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2018 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2018;320:379-396.
- Scherrer AU, von Wyl V, Yan W, et al. Emergence of acquired HIV-1 drug resistance almost stopped in Switzerland: A 15-year prospective cohort analysis. Clin Infect Dis. 2016;62(10):1310-1317.
- Shafer RW, Hertogs K, Zolopa AR, et al. High degree of interlaboratory reproducibility of Human Immunodeficiency Virus type 1 protease and reverse transcriptase sequencing of plasma samples from heavily treated patients. J Clin Microbiology. 2001; 39:1522-1529.
- Talbot A, Grant P, Taylor J, et al. Predicting tipranavir and darunavir resistance using genotypic, phenotypic, and virtual phenotypic resistance patterns: An independent cohort analysis of clinical isolates highly resistant to all other protease inhibitors. Antimicrob Agents Chemother. 2010;54:2473-2479.
- Tambuyzer L, Nijs S, Daems B, Picchio G, Vingerhoets J. Effect of mutations at position E138 in HIV-1 reverse transcriptase on phenotypic susceptibility and virologic response to etravirine. J Acquir Immune Defic Syndr. 2011;58:18-22.
- Tostevin A, White E, Dunn D, et al. Recent trends and patterns in HIV-1 transmitted drug resistance in the United Kingdom. HIV Med. 2017;18:204-213.
- Tural C, Ruiz L, Holtzer C, et al. Clinical utility of HIV-1 genotyping and expert advice: The Havana trial. AIDS. 2002;16:209-218.
- Vingerhoets J, Tambuyzer L, Azijn H, et al. Resistance profile of etravirine: Combined analysis of baseline genotypic and phenotypic data from the randomized, controlled phase III clinical studies. AIDS. 2010;24:503-514.
- Weinstock HS, Zaidi I, Heneine W, et al. The epidemiology of antiretroviral drug resistance among drug-naïve HIV-1-infected persons in 10 US cities. J Infect Dis. 2004;189:2174-2180.
- Wensing AM, Calvez V, Günthard HF, et al. 2017 update of the drug-resistance mutations in HIV-1. Top Antivir Med. 2017;24:132-141.
- Xu L, Pozniak A, Wildfire A, et al. Emergence and evolution of enfuvirtide resistance following long-term therapy involves heptad repeat 2 mutations within gp41. Antimicrob Agents Chemother. 2005;49:1113-1119.
- Yang W, Kouyos R., Scherrer A, et al. Assessing the paradox between transmitted and acquired HIV type 1 drug resistance mutations in the Swiss HIV cohort study from 1998 to 2012. J Infect Dis. 2015;212:28-38.
- Young , Fransen S, Greenberg KS, et al. Transmission of integrase strand-transfer inhibitor multidrug-resistant HIV-1: case report and response to raltegravir-containing antiretroviral therapy. Antivir Ther 2011;16:253-6.
- British HIV Association guidelines for the routine investigation and monitoring of adult HIV-1-infected individuals (2019 interim update). Available at: https://www.bhiva.org/file/DqZbRxfzlYtLg/Monitoring-Guidelines.pdf. Accessed April 10, 2019
- EACS Clinical Society. Guidelines 9.1. Available at: http://www.eacsociety.org/guidelines/eacs-guidelines/eacs-guidelines.html. Accessed April 10, 2019.
- Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV. Department of Health and Human Services. Available at https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf. Accessed April 10, 2019
- Panel on Antiretroviral Therapy and Medical Management of Children Living with HIV. Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection. Available at http://aidsinfo.nih.gov/contentfiles/lvguidelines/pediatricguidelines.pdf. Accessed April 10, 2019.
- World Health Organization. Guidelines on the public health response to pretreatment HIV drug resistance, July 2017. Geneva: World Health Organization; 2017. License: CC BY-NC-SA 3.0 IGO. Available at: https://apps.who.int/iris/bitstream/handle/10665/255880/9789241550055-en.... Accessed April 10, 2019.
- De Meyer S, Dierynck I, Lathouwers E, et al. Identification of mutations predictive of a diminished response to darunavir/ritonavir: Analysis of data from treatment-experienced patients in POWER 1, 2, 3, and DUET-1 and DUET-2. Programs and abstracts of the 6th European HIV Drug Resistance Workshop; March 26-28, 2008; Budapest, Hungary. Abstract 54.
- Gagliardini R, Ciccullo A, Borghetti A, et al. Impact of previous M184V on virological outcomes on switch to 3TC-based dual therapies. CROI 2018. March 4-7, 2018. Boston, MA. Abstract 498.
- Kim D, Ziebell R, Saduvala N, et al. Trend in transmitted HIV-1 ARV drug resistance-associated mutations: 10 HIV surveillance areas, US, 2007-2010. 20th Conference on Retroviruses and Opportunistic Infections; March 3-6, 2013; Atlanta, Georgia. Abstract 149.
- Misra K, Jamie Huang J, Daskalakis DC, Udeagu CC. Impact of PrEP on drug resistance and acute HIV infection, New York City, 2015-2017. Conference on Retroviruses and Opportunistic Infections (CROI). March 4-7, 2019. Seattle. Abstract 107.
- Ocfemia CB, Kim D, Ziebell R, et al. Prevalence and trends of transmitted drug resistance-associated mutations by duration of infection among persons newly diagnosed with HIV-1 infection: 5 states and 3 municipalities, US, 2006 to 2009. Presented at the 19th Conference on Retroviruses and Opportunistic Infections; March 5-8, 2012; Seattle, Washington. Abstract 730.
- Santoro MM, Fornabaio C, Malena M, et al. Susceptibility to bictegravir in highly ARV experienced patients after INSTI failure. Conference on Retroviruses and Opportunistic Infections. March 4-7, 2019. Abstract 550.
- Wang Z, Walits E, Gordon D, et al. Transmitted drug resistance and time of HIV infection, New York State, 2006-2013. Programs and abstacts of the 2015 Conference on Retroviruses and Opportunistic Infections. February 23-26, 2015;| Seattle, Washington. Abstract 599.
- Yang D, Lai J, Cal S, et al. HIV resistance-associated mutations observed in cell-associated DNA sequencing assay. Conference on Retroviruses and Opportunistic Infections. May 4-7, 2019. Seattle, WA. Abstract 543.
- Monogram Biosciences. Phenosense HIV drug resistance assay. Available at: http://www.monogrambio.com/hiv-tests/phenotype-assays/phenosense. Accessed April 11, 2019.
Thank you for visiting the AAHIVM Provider Education Center!
In order to continue, we will need you to create a profile. This will help us keep track of your education activity and CME accreditations.
NEW USERS CLICK HERE TO CREATE A PROFILE.
ALREADY CREATED YOUR AAHIVM PROFILE? CLICK HERE TO SIGN IN.
Featured Resources
Pair up with one of the Academy's experienced and credentialed providers for one-on-one guidance. No matter where you are on your journey, an Academy Mentor can help you reach your personal goals.
Contact
AAHIVM National Office
1705 DeSales Street NW, Suite 700
Washington, D.C. 20036
About
The American Academy of HIV Medicine is a professional organization that supports the HIV practitioner and promotes accessible, quality care for all Americans living with HIV disease. Our membership of HIV practitioners and credentialed HIV Specialists™, HIV Experts™, and HIV Pharmacists™ provide direct care to the majority of HIV patients in the US.