Because of increased survival of older persons with HIV, the frequency of comorbidities is expected to become higher in patients in the coming years. In the French Dat’AIDS study it was possible to use hospital records and compare those 50-74 years (16,436 “elderly” persons) with those 75 years and older (572 “geriatric” patients) for presence and frequency of comorbidities. These included: CVD, non-HIV related cancers, chronic pulmonary disease, diabetes, decreased glomerular filtration rate, evidence of hepatitis C or B, dyslipidemia, and low body mass index. Duration of HIV infection was slightly longer in the 50-74 year subgroup than the older subgroup. Of interest is that 93% of the oldest geriatric subgroup were diagnosed after 50 years of age and 8% after 75 years of age, suggesting later infection or delay in diagnosis. In this oldest subgroup all comorbidities were more frequent, except dyslipidemia. Also, among the geriatric subgroup 18.4% had 4 or more comorbidities compared to 4.3% in the 50-74 year elderly group. It is the geriatric group 75 years or older with HIV and a high frequency of comorbidities that will be the next major challenge for adequate care by the medical team.