Journal Article

Hospitalized Adults with HIV and COVID-19

THE BOTTOM LINE:

In a cohort study in New York City 30 hospitalized people living with HIV (PLWH) were compared to 90 similar patients without HIV for effects of COVID-19.  They were about 60 years of age, 20 % were women, and the frequency of White, Black, and Latino participants was similar (24% to 30%). There were no differences in laboratory markers or chest x-rays on admission. The need for mechanical ventilation, length of stay, and in-hospital mortality were the same for the two groups.  This is another small study indicating no difference in COVID-19 experience in PLWH.

ABSTRACT

Background

The spread of SARS-CoV-2 and the COVID-19 pandemic have caused significant morbidity and mortality worldwide. The clinical characteristics and outcomes of hospitalized patients with  SARS-CoV-2 and HIV co-infection remain uncertain.

Methods

We conducted a matched retrospective cohort study of adults hospitalized with a COVID-19 illness in New York City between March 3, 2020 and May 15, 2020.  We matched 30 people living with HIV (PLWH) with 90 control group patients without HIV based on age, sex, and race/ethnicity. Using electronic health record data, we compared demographic characteristics, clinical characteristics, and clinical outcomes between PLWH and control patients.

Results

In our study, the median age was 60.5 years (IQR 56.6-70.0), 20% were female, 27% were White, 30% were Black, and 24% were of Hispanic/Latino ethnicity.  There were no significant differences between PLWH and control patients in presenting symptoms, duration of symptoms prior to hospitalization, laboratory markers, or radiographic findings on chest x-ray. More patients without HIV required a higher level of supplemental oxygen on presentation than PLWH. There were no differences in the need for invasive mechanical ventilation during hospitalization, length of stay, or in-hospital mortality.

Conclusions

The clinical manifestations and outcomes of COVID-19 among patients with SARS-CoV-2 and HIV co-infection were not significantly different than patients without HIV co-infection.  However, PLWH were hospitalized with less severe hypoxemia, a finding that warrants further investigation.

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