Journal Article

Mortality Risk Index for Adults Aged 60 or Older With HIV

The average age for older adults with HIV is increasing. There is interest in identifying predictors of mortality outcomes as a guide to better management and to identify possible reversible risk factors. A French study entitled Dat’AIDS has relevant data on 1415 persons 60 years and older with HIV from 12 French hospitals, including 5 year-mortality experience. The investigators developed a list of possible mortality predictors and extracted data from the medical records on: age, CD4 count, non-HIV cancer, cardiovascular disease, glomerular filtration rate, cirrhosis, low body mass, and anemia and compared with mortality in the follow up period. They were able to develop a score that divided the participants into 4 categories from low risk to very high risk. This score showed good predictive statistics. Further information on the weights for each category and how to score results is available in the reference below. It should be noted that many of the same variables are included in the VACS score developed using data from a study of US Veterans. This index has been found to be very predictive of mortality in a large study of US adults with HIV (AC Justice et al. J Acquir Immune Defic Syndrome 2013;62:149-163). Both of these research efforts provide valuable information to assist the clinician in facing the management challenges of older adults with HIV.

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