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The question addressed by this report is whether the frequency of multimorbidity (MM) is increasing over time as persons with HIV continue to age. A large cohort of adults with HIV (22,969) gathered from various sites in the US under the auspices of NA-ACCORD (North American AIDS Cohort Collaboration on Research and Design) was used to investigate the cross sectional frequencies of MM by year from 2000 to 2009. Most of the participants in this study were white men with a baseline age of 40 years. MM was defined as 2 or more diseases or conditions from a list including: hypertension, diabetes mellitus, chronic kidney disease, hypercholesterolemia, end-stage liver disease or non-AIDS-related cancer. Between the beginning and the end of the 10-year study period the frequency of MM increased from 8.2% to 22.4%. After adjusting for age differences this trend remained significant. There was no difference by sex, although blacks had less MM than whites, and MM was highest in heterosexuals compared to men who had sex with men. Adjusted risk ratios comparing MM in 50-59 and 60 plus year olds to those less than 40 years were 1.69 and 1.95 respectively. Hypercholesterolemia and hypertension most frequently occurred together. Because of the apparent increase in MM over time, the authors emphasize a need for more coordinated and interdisciplinary efforts by medical services to prevent and treat MM.