Journal Article

Neuroimaging Suggests No Progression in Brain Pathology in Treated People with HIV

There is a concern among older adults with HIV about cognitive impairment and related changes in the brain. A longitudinal study of 123 virologically-suppressed HIV patients (median age 56 years) and 78 similar HIV-negative individuals (median age 57 years) used neuropsychological assessment and brain imaging at baseline and 2 years later to address this question. At baseline the people with HIV had poorer cognitive performance, lower gray matter volume with higher white matter intensity and abnormal striation than the comparison group. Importantly, longitudinally, there were no significant changes in any neuroimaging measures or other differences between the two groups. Also cognition was similar in the two groups over time. The conclusion reached by the authors is that with adequate treatment there is no evidence of deterioration of cognitive function or brain morphology over 2 years with adequate treatment. However, it is possible that a longer follow-up period might result in future changes. 

Purpose of this Program: The AAHIVM, ACRIA and AGS (collectively, the “Sponsors,” “we” or “us”) are sponsors of this Website and through it seek to address the unique needs and challenges that older adults of diverse populations living with HIV face as they age. However, the information in this Website is not meant to supplant the advice provided in a doctor-patient relationship.

General Disclaimer: is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your health care provider.



Phone: 202-659-0699
Fax: 202-659-0976


AAHIVM National Office
1627 Eye St NW Suite 835
Washington, D.C. 20006


The American Academy of HIV Medicine is a professional organization that supports the HIV practitioner and promotes accessible, quality care for all Americans living with HIV disease. Our membership of HIV practitioners and credentialed HIV Specialists™, HIV Experts™, and HIV Pharmacists™ provide direct care to the majority of HIV patients in the US.