Journal Article
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The Relationship of Physical Performance with HIV Disease and Mortality

The article by Greene and others shows that HIV infection is associated with a decline in overall function and this decline can predict mortality. In this prospective cohort of current and former injection drug users with or at high risk of HIV-infection, an easily administered test of lower extremity function, commonly used in the geriatric population, showed that HIV-infected patients performed worse and had decreased survival, independent of other factors. Whether targeted interventions can prevent this functional decline remains to be determined.

The relationship of physical performance with HIV disease and mortality

Meredith Greene, Kenneth Covinsky, Jacquie Astemborski, Damani A. Piggott, Todd Brown, Sean Leng, Noya Galai, Shruti H. Mehta, Jack Guralnik, Kushang V. Patel and Gregory D. Kirk

Objective: To evaluate whether HIV infection was associated with reduced physical performance, and to examine if reduced physical performance predicted mortality in our aging cohort of HIV-infected and HIV-uninfected persons.

Design: Prospective, observational cohort of current and former injection drug users in the AIDS Linked to the IntraVenous Experience study in Baltimore, Maryland, USA.

Methods: The Short Physical Performance Battery (SPPB) was used as an objective measure of physical performance and measured semiannually along with behavioral and demographic data. Correlates of reduced physical performance (SPPB score

Purpose of this Program: The AAHIVM, ACRIA and AGS (collectively, the “Sponsors,” “we” or “us”) are sponsors of this Website and through it seek to address the unique needs and challenges that older adults of diverse populations living with HIV face as they age. However, the information in this Website is not meant to supplant the advice provided in a doctor-patient relationship.

General Disclaimer: is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your health care provider.



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