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The article by Greene and others shows that HIV infection is associated with a decline in overall function and this decline can predict mortality. In this prospective cohort of current and former injection drug users with or at high risk of HIV-infection, an easily administered test of lower extremity function, commonly used in the geriatric population, showed that HIV-infected patients performed worse and had decreased survival, independent of other factors. Whether targeted interventions can prevent this functional decline remains to be determined.
Meredith Greene, Kenneth Covinsky, Jacquie Astemborski, Damani A. Piggott, Todd Brown, Sean Leng, Noya Galai, Shruti H. Mehta, Jack Guralnik, Kushang V. Patel and Gregory D. Kirk
Objective: To evaluate whether HIV infection was associated with reduced physical performance, and to examine if reduced physical performance predicted mortality in our aging cohort of HIV-infected and HIV-uninfected persons.
Design: Prospective, observational cohort of current and former injection drug users in the AIDS Linked to the IntraVenous Experience study in Baltimore, Maryland, USA.
Methods: The Short Physical Performance Battery (SPPB) was used as an objective measure of physical performance and measured semiannually along with behavioral and demographic data. Correlates of reduced physical performance (SPPB score