Journal Article

Viral Suppression Reduces Increased Cancer Risks seen in HIV Infected Veterans

HIV-positive veterans (n=42,441) and demographically matched uninfected veterans (n=104,712) from (1999-2015) were followed for 16 years in this study–98% were men. Long-term viral suppression was associated with a reduction in the increased risk by more than 90% for ADC (AIDS defining cancers). There was a 23% reduction for virus-related NADC (non–AIDS-defining cancer), but absent for NADC not caused by virus. For the first two groups, 60% of the risk reduction was attributed to early suppression. However, even with long-term viral suppression, the cancer risk remained higher than that seen in the uninfected control group. Nevertheless, the findings suggest that early, sustained ART, which results in long-term viral suppression, prevents cancer, with a marked reduction in ADC risk and a meaningful (but much less pronounced) reduction in virus-related NADC risk.

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