HIV & Aging: Journal Articles

A large study of about 20,000 individuals with HIV including women, men who have sex with women, and men who have sex with men (MSM) was done over 5 years. The goal was to assess the contribution of gender, age, and sexual orientation on person-time spent in: retention in care, ART use, and viral suppression.

An ongoing study of men 50-75 years of age with HIV (279) or at risk for HIV (379) found that about 40% suffered one or more falls over a 2-year period. In both groups with two or more falls, illicit drug use, taking diabetes medications or depression medications, and peripheral neuropathy were the most frequent risk factors.

A total of 782 gay couples, median age 40 years, with one partner HIV positive and the other negative were followed for 3 years.  There were 76,000 episodes of anal intercourse without condoms. The investigators reported no episodes of HIV transmission from the positive to the negative partner.

In a cohort of 2,308 persons, mean age 60, hospitalized for heart failure, there were 374 with HIV.  On follow-up for short-term readmission and longer-term cardiovascular mortality, the adults with HIV had significantly higher readmissions as well as greater cardiovascular and all-cause mortality rates compared to the HIV-negative group.

HIV is associated with an increased risk of stroke from both the effect of the virus and known risk factors.  It appears that traditional risk factors, such as hypertension and smoking, may be even more elevated as risk factors.

Smoking cessation and blood pressure control are recommended for prevention and use of statins is suggested, pending the result of an ongoing clinical trial. Cardiovascular disease is a major comorbidity in older adults with HIV and demands attention.

A study of 109 persons living with HIV and 92 in an uninfected comparison group with an average age of 51 showed a relationship of the metabolic syndrome (high blood pressure, elevated triglycerides, low HDL cholesterol, increased waste circumference, and high blood sugar) with a deficit on a comprehensive neurocognitive measure.
Nonalcoholic fatty liver disease is common in persons with HIV. Metabolic syndrome (hypertension, dyslipidemia, increased waist circumference and insulin resistance) is among the major causes.
In 57 adults with HIV measurements of homocysteine, vitamins and neurocognitve performance were made. There were correlations between elevated homocysteine level and worse performance on verbal fluency and executive function.
In a study of 400 older persons with HIV and an average age of 59 years the key predictors of the most frequent comorbidities of elevated cholesterol, hypertension, and depression/anxiety were age and duration of HIV infection.

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The American Academy of HIV Medicine is a professional organization that supports the HIV practitioner and promotes accessible, quality care for all Americans living with HIV disease. Our membership of HIV practitioners and credentialed HIV Specialists™, HIV Experts™, and HIV Pharmacists™ provide direct care to the majority of HIV patients in the US.