A cross-sectional study assessed 3258 adults (2248 MSM, 373 heterosexual men, and 637 women) with HIV in the UK. Median age was 45, 56% reported physical symptoms of distress; 27% depression; 22% anxiety; 38% functional problems. They found that the prevalence of depression and anxiety decreased with age while functional problems increased with age. There was no association between age and physical symptoms of distress. Longer duration of living with HIV infection was strongly associated with higher prevalence of physical distress symptoms, depression, anxiety, and functional problems.