This is a retrospective controlled cohort study of deaths in the ART era (1996-2012) in British Columbia. The mortality rate of HIV-infected patients has declined by 96% but remains about 3 times higher than in the HIV-uninfected population. Deaths due to non-HIV related causes now account for about 75% of all deaths in the HIV infected population. Cancers remain the largest cause of death in this HIV-infected cohort.