HIV & Aging: Journal Articles

A cross-sectional study assessed 3258 adults (2248 MSM, 373 heterosexual men, and 637 women) with HIV in the UK. Median age was 45, 56% reported physical symptoms of distress; 27% depression; 22% anxiety; 38% functional problems. They found that the prevalence of depression and anxiety decreased with age while functional problems increased with age. There was no association between age and physical symptoms of distress. Longer duration of living with HIV infection was strongly associated with higher prevalence of physical distress symptoms, depression, anxiety, and functional problems.

This study assessed 29 HIV-positive adults over the age of 50 living in U.S. rural counties. Using thematic content analysis, they examined the nexus of aging and HIV to identify factors that affects overall health, engagement in care, and medication adherence These older adults were more concerned with health conditions other than HIV. Lack of concern for HIV were attributed to fewer HIV-related complications, degree of comfortability and the number of years living with HIV.

National surveys were used to assess the distribution and characteristics of malignancy-related deaths among HIV patients in 2010, and compared them to 2000 and 2005. Cancer is the leading cause of mortality in the HIV-infected patients studied. The risk of malignancies, including non-AIDS-related cancers, is higher in HIV patients than in the general population. Smoking is reported to be the primary risk factor in non-AIDS-related cancer, particularly lung cancer.

A randomized control trial assessed HIV knowledge, treatment, beliefs and attitude of women who had previously received PMTCT (prevention-of-mother-to-child-transmission) [PMTCT] and were about to commence ART. Of the 320 women studied, mean age was 33, 106 had previously received PMTCT, while 214, had never received ART. Using multivariate linear regression analysis, higher HIV insights was associated with prior PMTCT participation. ART naïve-women expressed stronger beliefs that ART would pose a problem, when compared to those who had previously received PMTCT.

This study conducted an integrative review of 29 articles to assess and compare emerging themes in the social network component of rural versus urban-dwelling older people living with HIV (OPLWH). Themes discovered in both rural and urban-based literature were similar, and revealed perceived lack of social networks and social support, heightened stigma, fragmented social support, and increased social isolation among OALWH. Unlike urban communities, rural OALWH faced added challenges such as socioeconomic burdens, lack of quality healthcare facilities, and inadequate HIV resources.

In a 2016 study researchers examined patterns of cardiovascular disease (CVD) mortality for HIV-infected adults between 1999-2013. Total and proportionate cardiovascular disease mortality in HIV-infected adults was compared to the general population and those with another chronic inflammatory condition, inflammatory polyarthroplasty. Total mortality in HIV-infected men and women decreased from 15,739 to 8660. CVD mortality significantly increased from 307 to 400 during the same period.

A recent systematic review examined the safety and effectiveness of aerobic exercise interventions on several health outcomes in HIV-infected adults. This was an update of a previous systematic 2010 review of 14 studies. Authors searched 11 databases for studies published between 2009 and April 2013. Randomized controlled trials of HIV-infected adults that compared aerobic exercise to no exercise or another exercise intervention performed at least three times per week for at least four weeks were included.

In a retrospective sub study using the Veterans Administration (VA) database, the authors looked at health disparities in the treatment of common comorbidities among HIV-infected veterans. It is known that health disparities exist between black and non-black HIV-infected patients; blacks are less likely to be in care, to receive ART and to have viral load suppression. The authors looked at the cohort of approximately 25,000 HIV-infected veterans in care during 2013.

The British Medical Journal, referring to a report by the UK’s Terrence Higgins Trust, Uncharted Territory, described the report findings as a “Time Bomb”. The report states that “the social care, healthcare and welfare systems aren’t ready for this new and fast-growing ageing generation”. Study respondents reported they would have no one to help them when they needed support for daily tasks. Over 80% are concerned about accessing adequate social care in the future.

By Rebecca Erenrich, MPH
Research and Community Engagement Coordinator
​ACRIA San Francisco Offices


Purpose of this Program: The AAHIVM, ACRIA and AGS (collectively, the “Sponsors,” “we” or “us”) are sponsors of this Website and through it seek to address the unique needs and challenges that older adults of diverse populations living with HIV face as they age. However, the information in this Website is not meant to supplant the advice provided in a doctor-patient relationship.

General Disclaimer: is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your health care provider.



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