AIDS-related causes of death have decreased with better HIV treatment, and non-AIDS related causes of death have increased. A study of 5285 Italians aged 15-74 years with diagnosed AIDS was conducted from 2006-2011. Among this group 1220 individuals were found to be deceased, and their death certificates were reviewed for all causes associated with death. Cardiovascular disease and diabetes were mentioned on death certificates, both with 13 fold higher frequencies when compared to a 2,019 age-sex matched sample derived from 952,019 deceased non-AIDS persons. Cardiovascular diseases listed on the death certificates were: hypertension, ischemic heart disease, other forms of heart disease, and cerebrovascular disease. Most of the elevation occurred in those less than 50 years of age. The results of this study suggest the need to start cardiovascular disease and diabetes prevention and treatment efforts at an earlier age in adults with HIV.