Browse by Topic

Cardiovascular Disease

AIDS-related causes of death have decreased with better HIV treatment, and non-AIDS related causes of death have increased. A study of 5285 Italians aged 15-74 years with diagnosed AIDS was conducted from 2006-2011. Among this group 1220 individuals were found to be deceased, and their death certificates were reviewed for all causes associated with death. Cardiovascular disease and diabetes were mentioned on death certificates, both with 13 fold higher frequencies when compared to a 2,019 age-sex matched sample derived from 952,019 deceased non-AIDS persons.

Diabetes

AIDS-related causes of death have decreased with better HIV treatment, and non-AIDS related causes of death have increased. A study of 5285 Italians aged 15-74 years with diagnosed AIDS was conducted from 2006-2011. Among this group 1220 individuals were found to be deceased, and their death certificates were reviewed for all causes associated with death. Cardiovascular disease and diabetes were mentioned on death certificates, both with 13 fold higher frequencies when compared to a 2,019 age-sex matched sample derived from 952,019 deceased non-AIDS persons.

HIV-Age

Persons 50 years and older tend to have late HIV diagnoses, which complicates management and also serve as a source for HIV transmission. The factors that lead to this situation are not clear. Interviews about possible reasons were completed on 20 persons who had a late HIV diagnosis. The results suggest that older persons do not see themselves at risk for HIV.

There is a concern among older adults with HIV about cognitive impairment and related changes in the brain. A longitudinal study of 123 virologically-suppressed HIV patients (median age 56 years) and 78 similar HIV-negative individuals (median age 57 years) used neuropsychological assessment and brain imaging at baseline and 2 years later to address this question. At baseline the people with HIV had poorer cognitive performance, lower gray matter volume with higher white matter intensity and abnormal striation than the comparison group.

As part of stroke prevention, especially with vascular symptoms, carotid endarterectomy or carotid stenting are often performed. With apparent increased strokes in adults with HIV, a question arises about the frequency and age of such surgical procedures. Using a very large sample of hospital admissions from the Healthcare Cost and Utilization Project, the age, sex, other demographics, comorbidities, and other related variables were collected from medical records on adults with HIV (HIV+) and without HIV (HIV-) over a 10-year period (2004-2014).

Increased vascular stiffness has been found in adults with HIV. A key question is if the vascular stiffness is related to cognitive decline. This issue was investigated in the Women’s Interagency HIV Study, which includes 1662 women with 72% HIV positive and the remainder, similar in demographics, but who are HIV negative. Carotid ultrasound at a single baseline visit was used as a measure of stiffness and longitudinal neuropsychological test results as a measure of cognitive status were determined from 2004-2016.

With mortality from HIV reduced there are more older persons living with HIV. The concern is that diseases and conditions associated with aging will become frequent and result in multimorbidity (MM) in this subgroup. A number of reports, including the one featured above, have reported this increase in MM. However, investigators from Switzerland present a literature review and suggest a possible recent reduction in the frequency of various comorbidities.

Aging

Persons 50 years and older tend to have late HIV diagnoses, which complicates management and also serve as a source for HIV transmission. The factors that lead to this situation are not clear. Interviews about possible reasons were completed on 20 persons who had a late HIV diagnosis. The results suggest that older persons do not see themselves at risk for HIV.

There is a concern among older adults with HIV about cognitive impairment and related changes in the brain. A longitudinal study of 123 virologically-suppressed HIV patients (median age 56 years) and 78 similar HIV-negative individuals (median age 57 years) used neuropsychological assessment and brain imaging at baseline and 2 years later to address this question. At baseline the people with HIV had poorer cognitive performance, lower gray matter volume with higher white matter intensity and abnormal striation than the comparison group.

As part of stroke prevention, especially with vascular symptoms, carotid endarterectomy or carotid stenting are often performed. With apparent increased strokes in adults with HIV, a question arises about the frequency and age of such surgical procedures. Using a very large sample of hospital admissions from the Healthcare Cost and Utilization Project, the age, sex, other demographics, comorbidities, and other related variables were collected from medical records on adults with HIV (HIV+) and without HIV (HIV-) over a 10-year period (2004-2014).

Increased vascular stiffness has been found in adults with HIV. A key question is if the vascular stiffness is related to cognitive decline. This issue was investigated in the Women’s Interagency HIV Study, which includes 1662 women with 72% HIV positive and the remainder, similar in demographics, but who are HIV negative. Carotid ultrasound at a single baseline visit was used as a measure of stiffness and longitudinal neuropsychological test results as a measure of cognitive status were determined from 2004-2016.

With mortality from HIV reduced there are more older persons living with HIV. The concern is that diseases and conditions associated with aging will become frequent and result in multimorbidity (MM) in this subgroup. A number of reports, including the one featured above, have reported this increase in MM. However, investigators from Switzerland present a literature review and suggest a possible recent reduction in the frequency of various comorbidities.

Testing

Persons 50 years and older tend to have late HIV diagnoses, which complicates management and also serve as a source for HIV transmission. The factors that lead to this situation are not clear. Interviews about possible reasons were completed on 20 persons who had a late HIV diagnosis. The results suggest that older persons do not see themselves at risk for HIV.

Neurology

There is a concern among older adults with HIV about cognitive impairment and related changes in the brain. A longitudinal study of 123 virologically-suppressed HIV patients (median age 56 years) and 78 similar HIV-negative individuals (median age 57 years) used neuropsychological assessment and brain imaging at baseline and 2 years later to address this question. At baseline the people with HIV had poorer cognitive performance, lower gray matter volume with higher white matter intensity and abnormal striation than the comparison group.

Vascular

Increased vascular stiffness has been found in adults with HIV. A key question is if the vascular stiffness is related to cognitive decline. This issue was investigated in the Women’s Interagency HIV Study, which includes 1662 women with 72% HIV positive and the remainder, similar in demographics, but who are HIV negative. Carotid ultrasound at a single baseline visit was used as a measure of stiffness and longitudinal neuropsychological test results as a measure of cognitive status were determined from 2004-2016.

Pages

Connect

Phone: 202-659-0699
Fax: 202-659-0976

Contact

AAHIVM National Office
1705 DeSales Street NW, Suite 700
Washington, D.C. 20036

About

The American Academy of HIV Medicine is a professional organization that supports the HIV practitioner and promotes accessible, quality care for all Americans living with HIV disease. Our membership of HIV practitioners and credentialed HIV Specialists™, HIV Experts™, and HIV Pharmacists™ provide direct care to the majority of HIV patients in the US.